The gastrointestinal stimulus to insulin release
نویسندگان
چکیده
منابع مشابه
The stimulus-secretion coupling of glucose-induced insulin release. Effect of exogenous pyruvate on islet function.
1. In isolated pancreatic islets, pyruvate causes a shift to the left of the sigmoidal curve relating the rate of insulin release to the ambient glucose concentration. The magnitude of this effect is related to the concentration of pyruvate (5--90 mM) and, at a 30 mM concentration, is equivalent to that evoked by 2 mM-glucose. Pyruvate also enhances insulin release in the presence of fructose, ...
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Plasma insulin levels are determined mainly by the rate of exocytosis of the insulin-containing large dense core vesicles (LDCVs) of pancreatic islet beta-cells. This process involves the recruitment of LDCVs to the plasma membrane, where they are docked by the assembly of multiprotein SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complexes. However, fusion of th...
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Concomitant measurements of plasma insulin levels were performed on all samples of blood obtained from 1,408 patients undergoing a diagnostic oral glucose tolerance test. These patients had no prior diagnosis of diabetes but qualified for the study because of either suspicious history, family history, or signs and symptoms. Graphic display of the findings, with insulin plotted as percent increa...
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Neurotransmitter release is a steep function of the intracellular calcium ion concentration ([Ca(2+)](i)) at the release sites. Both the Ca(2+) amplitude and the time course appear to be important for specifying neurotransmitter release. Ca(2+) influx regulates the number of vesicles exocytosed as well as the amount of neurotransmitter each individual vesicle releases. In our study we stimulate...
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NH4+ caused a dose-related, rapid, and reversible inhibition of glucose-stimulated insulin release by isolated rat islets. It also inhibited glyceraldehyde-, Ba2+-, and sulfonylurea-stimulated insulun secretion. NH4+ failed to affect glucose utilization and oxidation, glucose-stimulated proinsulin biosynthesis, the concentration of ATP, AD, and AMP, and the intracellular pH. NH4+ also failed to...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1969
ISSN: 0021-9738
DOI: 10.1172/jci106111